I'm told this is the opening video from his Comedy Central roast back in 2006, which I missed.
Guests at the roast included Andy Dick (as the "love child" of James T. Kirk and Spock), Farrah Fawcett, Lisa Lampanelli, Artie Lange, Nichelle Nichols, Patton Oswalt, Kevin Pollak, Jeffrey Ross, George Takei, Betty White, and Fred Willard performing the roasting duties. Special, pre-taped, guest appearances were made by Leonard Nimoy, Sandra Bullock, Ben Stiller, Sarah Silverman, Jimmy Kimmel, and Clint Howard.
Other celebrities were shown prominently in the audience, including Adrian Zmed, David Carradine, Roger Corman, Brent Spiner, Jeri Ryan, Rene Auberjonois, Rosalind Chao, Mark Valley, Carrie Fisher, Scott Hamilton, country music star Brad Paisley, Reno 911! stars Cedric Yarbrough and Niecy Nash, and stand-up comedian Brian Posehn. Women dressed as green Orion slave girls can be clearly seen tending bar.
The tagline for this roast was: "The Shat hits the fan."